Ferroptosis in Chronic Liver Diseases: Opportunities and Challenges

Xiaoxi Zhou; Xiaoxi Zhou; Yadong Fu; Yadong Fu; Yadong Fu; Yadong Fu; Wei Liu; Wei Liu; Yongping Mu; Yongping Mu; Hua Zhang; Hua Zhang; Jiamei Chen; Jiamei Chen; Ping Liu; Ping Liu; Ping Liu

doi:10.3389/fmolb.2022.928321

Frontiers in Molecular Biosciences (Jun 2022)

Ferroptosis in Chronic Liver Diseases: Opportunities and Challenges

Xiaoxi Zhou,
Xiaoxi Zhou,
Yadong Fu,
Yadong Fu,
Yadong Fu,
Yadong Fu,
Wei Liu,
Wei Liu,
Yongping Mu,
Yongping Mu,
Hua Zhang,
Hua Zhang,
Jiamei Chen,
Jiamei Chen,
Ping Liu,
Ping Liu,
Ping Liu

Affiliations

Xiaoxi Zhou: Key Laboratory of Liver and Kidney Diseases, Ministry of Education, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
Xiaoxi Zhou: Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai, China
Yadong Fu: Key Laboratory of Liver and Kidney Diseases, Ministry of Education, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
Yadong Fu: Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai, China
Yadong Fu: Institute of Interdisciplinary Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Yadong Fu: State Key Laboratory of Cell Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China
Wei Liu: Key Laboratory of Liver and Kidney Diseases, Ministry of Education, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
Wei Liu: Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai, China
Yongping Mu: Key Laboratory of Liver and Kidney Diseases, Ministry of Education, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
Yongping Mu: Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai, China
Hua Zhang: Key Laboratory of Liver and Kidney Diseases, Ministry of Education, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
Hua Zhang: Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai, China
Jiamei Chen: Key Laboratory of Liver and Kidney Diseases, Ministry of Education, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
Jiamei Chen: Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai, China
Ping Liu: Key Laboratory of Liver and Kidney Diseases, Ministry of Education, Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
Ping Liu: Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai, China
Ping Liu: Institute of Interdisciplinary Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China

DOI: https://doi.org/10.3389/fmolb.2022.928321
Journal volume & issue: Vol. 9

Abstract

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Ferroptosis, an iron-dependent non-apoptotic cell death characterized by lipid peroxidation, is a cell death pathway discovered in recent years. Ferroptosis plays an important role in tumors, ischemia-reperfusion injury, neurological diseases, blood diseases, etc. Recent studies have shown the importance of ferroptosis in chronic liver disease. This article summarizes the pathological mechanisms of ferroptosis involved in System Xc−, iron metabolism, lipid metabolism, and some GPX4-independent pathways, and the latest research on ferroptosis in chronic liver diseases such as alcoholic liver disease, non-alcoholic fatty liver disease, liver fibrosis, hepatocellular carcinoma. In addition, the current bottleneck issues that restrict the research on ferroptosis are proposed to provide ideas and strategies for exploring new therapeutic targets for chronic liver diseases.

Published in Frontiers in Molecular Biosciences

ISSN: 2296-889X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/molecular-biosciences

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