Frontiers in Pharmacology (Jul 2023)

Research progress on Cornus officinalis and its active compounds in the treatment of diabetic nephropathy

  • Chenguang Wu,
  • Jingjing Wang,
  • Rui Zhang,
  • Hailing Zhao,
  • Xin Li,
  • Lifan Wang,
  • Peng Liu,
  • Ping Li

DOI
https://doi.org/10.3389/fphar.2023.1207777
Journal volume & issue
Vol. 14

Abstract

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Diabetic nephropathy (DN) is a kidney disorder secondary to diabetes and is one of the main diabetic microvascular complications. As the number of diabetic patients grows, DN has become the leading cause of chronic kidney disease in China. Unfortunately, no definitive cure currently exists for DN. Cornus officinalis (CO), frequently utilized in clinical settings for diabetes mellitus treatment, has proven vital in both preventing and treating DN. This article explores the pathogenesis of DN and how CO and its active compounds regulate glucose and lipid metabolism, exhibit anti-inflammatory properties, inhibit oxidative stress, regulate podocytes, and manage autophagy. The mechanism and role of and its active compounds in the treatment of DN are discussed.

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