A metabolic switch in proteasome inhibitor-resistant multiple myeloma ensures higher mitochondrial metabolism, protein folding and sphingomyelin synthesis

• Lenka Besse,
• Andrej Besse,
• Max Mendez-Lopez,
• Katerina Vasickova,
• Miroslava Sedlackova,
• Petr Vanhara,
• Marianne Kraus,
• Jürgen Bader,
• Renan B. Ferreira,
• Ronald K. Castellano,
• Brian K. Law,
• Christoph Driessen

Affiliations

Lenka Besse

Experimental Oncology and Hematology, Department of Oncology and Hematology, St. Gallen Cantonal Hospital, St. Gallen, Switzerland

Andrej Besse

Experimental Oncology and Hematology, Department of Oncology and Hematology, St. Gallen Cantonal Hospital, St. Gallen, Switzerland

Max Mendez-Lopez

Experimental Oncology and Hematology, Department of Oncology and Hematology, St. Gallen Cantonal Hospital, St. Gallen, Switzerland

Katerina Vasickova

Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic

Miroslava Sedlackova

Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic

Petr Vanhara

Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic

Marianne Kraus

Experimental Oncology and Hematology, Department of Oncology and Hematology, St. Gallen Cantonal Hospital, St. Gallen, Switzerland

Jürgen Bader

Experimental Oncology and Hematology, Department of Oncology and Hematology, St. Gallen Cantonal Hospital, St. Gallen, Switzerland

Renan B. Ferreira

Department of Chemistry, University of Florida, Gainesville, FL, USA

Ronald K. Castellano

Department of Chemistry, University of Florida, Gainesville, FL, USA;UF-Health Cancer Center, University of Florida, Gainesville, FL, USA

Brian K. Law

UF-Health Cancer Center, University of Florida, Gainesville, FL, USA;Department of Pharmacology & Therapeutics, University of Florida, Gainesville, FL, USA

Christoph Driessen

Experimental Oncology and Hematology, Department of Oncology and Hematology, St. Gallen Cantonal Hospital, St. Gallen, Switzerland