Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects

Xiaojin Zhang; Yan Li; Y. Eugene Chen; Jihua Chen; Peter X. Ma

doi:10.1038/ncomms10376

Nature Communications (Jan 2016)

Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects

Xiaojin Zhang,
Yan Li,
Y. Eugene Chen,
Jihua Chen,
Peter X. Ma

Affiliations

Xiaojin Zhang: Department of Biologic and Materials Science, University of Michigan
Yan Li: Department of Biologic and Materials Science, University of Michigan
Y. Eugene Chen: Department of Cardiac Surgery, Frankel Cardiovascular Center, University of Michigan
Jihua Chen: Department of Prosthodontics, State Key Laboratory of Military Stomatology, School of Stomatology, The Fourth Military Medical University
Peter X. Ma: Department of Biologic and Materials Science, University of Michigan

DOI: https://doi.org/10.1038/ncomms10376
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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A challenge in regenerative medicine is the development of cell-free, non-immunogenic miRNA-delivering scaffolds. Here the authors design a cell-free scaffold capable of efficient and prolonged delivery of miRNA-26a to endogenous cells and show that it can regenerate a full-thickness calvarial bone defect in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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