Nature Communications (Sep 2019)
Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ
- Lina Ding,
- Ying Su,
- Anne Fassl,
- Kunihiko Hinohara,
- Xintao Qiu,
- Nicholas W. Harper,
- Sung Jin Huh,
- Noga Bloushtain-Qimron,
- Bojana Jovanović,
- Muhammad Ekram,
- Xiaoyuan Zi,
- William C. Hines,
- Maša Alečković,
- Carlos Gil del Alcazar,
- Ryan J. Caulfield,
- Dennis M. Bonal,
- Quang-De Nguyen,
- Vanessa F. Merino,
- Sibgat Choudhury,
- Gabrielle Ethington,
- Laura Panos,
- Michael Grant,
- William Herlihy,
- Alfred Au,
- Gedge D. Rosson,
- Pedram Argani,
- Andrea L. Richardson,
- Deborah Dillon,
- D. Craig Allred,
- Kirsten Babski,
- Elizabeth Min Hui Kim,
- Charles H. McDonnell,
- Jon Wagner,
- Ron Rowberry,
- Kristie Bobolis,
- Celina G. Kleer,
- E. Shelley Hwang,
- Joanne L. Blum,
- Simona Cristea,
- Piotr Sicinski,
- Rong Fan,
- Henry W. Long,
- Saraswati Sukumar,
- So Yeon Park,
- Judy E. Garber,
- Mina Bissell,
- Jun Yao,
- Kornelia Polyak
Affiliations
- Lina Ding
- Department of Medical Oncology, Dana-Farber Cancer Institute Boston
- Ying Su
- Department of Medical Oncology, Dana-Farber Cancer Institute Boston
- Anne Fassl
- Department of Cancer Biology, Dana-Farber Cancer Institute Boston
- Kunihiko Hinohara
- Department of Medical Oncology, Dana-Farber Cancer Institute Boston
- Xintao Qiu
- Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute
- Nicholas W. Harper
- Department of Medical Oncology, Dana-Farber Cancer Institute Boston
- Sung Jin Huh
- Department of Medical Oncology, Dana-Farber Cancer Institute Boston
- Noga Bloushtain-Qimron
- Department of Medical Oncology, Dana-Farber Cancer Institute Boston
- Bojana Jovanović
- Department of Medical Oncology, Dana-Farber Cancer Institute Boston
- Muhammad Ekram
- Department of Medical Oncology, Dana-Farber Cancer Institute Boston
- Xiaoyuan Zi
- Department of Biomedical Engineering, Yale University
- William C. Hines
- Lawrence Berkeley National Laboratory
- Maša Alečković
- Department of Medical Oncology, Dana-Farber Cancer Institute Boston
- Carlos Gil del Alcazar
- Department of Medical Oncology, Dana-Farber Cancer Institute Boston
- Ryan J. Caulfield
- Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute Boston
- Dennis M. Bonal
- Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute Boston
- Quang-De Nguyen
- Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute Boston
- Vanessa F. Merino
- Johns Hopkins University School of Medicine
- Sibgat Choudhury
- Department of Medical Oncology, Dana-Farber Cancer Institute Boston
- Gabrielle Ethington
- Baylor-Charles A. Sammons Cancer Center
- Laura Panos
- Baylor-Charles A. Sammons Cancer Center
- Michael Grant
- Baylor-Charles A. Sammons Cancer Center
- William Herlihy
- Baylor-Charles A. Sammons Cancer Center
- Alfred Au
- University of California San Francisco Helen Diller Family Comprehensive Cancer Center
- Gedge D. Rosson
- Johns Hopkins University School of Medicine
- Pedram Argani
- Johns Hopkins University School of Medicine
- Andrea L. Richardson
- Department of Pathology, Brigham and Women’s Hospital
- Deborah Dillon
- Department of Pathology, Brigham and Women’s Hospital
- D. Craig Allred
- Department of Pathology, Washington University School of Medicine
- Kirsten Babski
- Sutter Roseville Medical Center
- Elizabeth Min Hui Kim
- Sutter Roseville Medical Center
- Charles H. McDonnell
- Sutter Roseville Medical Center
- Jon Wagner
- Sutter Roseville Medical Center
- Ron Rowberry
- Sutter Roseville Medical Center
- Kristie Bobolis
- Sutter Roseville Medical Center
- Celina G. Kleer
- Department of Pathology, University of Michigan
- E. Shelley Hwang
- University of California San Francisco Helen Diller Family Comprehensive Cancer Center
- Joanne L. Blum
- Baylor-Charles A. Sammons Cancer Center
- Simona Cristea
- Department of Data Science, Dana-Farber Cancer Institute Boston
- Piotr Sicinski
- Department of Cancer Biology, Dana-Farber Cancer Institute Boston
- Rong Fan
- Department of Biomedical Engineering, Yale University
- Henry W. Long
- Department of Medical Oncology, Dana-Farber Cancer Institute Boston
- Saraswati Sukumar
- Johns Hopkins University School of Medicine
- So Yeon Park
- Department of Pathology, Seoul National University College of Medicine
- Judy E. Garber
- Department of Medical Oncology, Dana-Farber Cancer Institute Boston
- Mina Bissell
- Lawrence Berkeley National Laboratory
- Jun Yao
- MD Anderson Cancer Center
- Kornelia Polyak
- Department of Medical Oncology, Dana-Farber Cancer Institute Boston
- DOI
- https://doi.org/10.1038/s41467-019-12125-5
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Myoepithelial cells prevent tumour growth and invasion in DCIS. Here, the authors show that p63 and TCF7 cooperate to regulate a transcription factor network for the maintenance of normal myoepithelial function and altered expression of these genes perturb myoepithelial function in DCIS to promote invasive progression.
