Experimental Hematology & Oncology (Dec 2012)

Intravascular CNS lymphoma: Successful therapy using high-dose methotrexate-based polychemotherapy

  • Kebir Sied,
  • Kuchelmeister Klaus,
  • Niehusmann Pitt,
  • Nelles Michael,
  • Kim Young,
  • Thanendrarajan Sharmilan,
  • Schäfer Niklas,
  • Stuplich Moritz,
  • Mack Frederic,
  • Scheffler Björn,
  • Urbach Horst,
  • Glas Martin,
  • Herrlinger Ulrich

DOI
https://doi.org/10.1186/2162-3619-1-37
Journal volume & issue
Vol. 1, no. 1
p. 37

Abstract

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Abstract Intravascular diffuse large B-cell lymphoma limited to the CNS (cIVL) is a very rare malignant disorder characterized by a selective accumulation of neoplastic lymphocytes (usually B cells) within the lumen of CNS blood vessels but not in the brain parenchyma. In the past, treatment of cIVL with anthracycline-based regimens was unsatisfactory with very short survival times. In the case of cIVL presented here, high-dose methotrexate-based polychemotherapy according to the Bonn protocol plus rituximab therapy was successful and led to a complete clinical and MRI remission which is ongoing 29 months after diagnosis.

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