Case Reports in Pediatrics (Jan 2012)

Male Child with Van Wyk-Grumbach's Syndrome and Other Complications of Long-Standing Primary Hypothyroidism: A Case Report

  • Ahmed Omran,
  • Jing Peng,
  • Biswas Shrestha,
  • Muhammad Usman Ashhab,
  • Fei Yin

DOI
https://doi.org/10.1155/2012/352751
Journal volume & issue
Vol. 2012

Abstract

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Primary hypothyroidism in the juvenile population generally leads to retardation of linear growth and delay or even arrest of puberty. However, in rare conditions, children with long-standing hypothyroidism present with signs of Van Wyk-Grumbach's syndrome (VWGS) which include juvenile hypothyroidism, delayed bone age, and pseudoprecocious puberty. We report a rare case of prepubertal male child from Asian origin, presented with long-standing untreated hypothyroidism complicated with VWGS and other complications including obesity, short stature, hepatomegaly, asymptomatic mild pericardial effusion, and pituitary hyperplasia.