Medical Institute of Developmental Disabilities Research, Showa University, Tokyo, Japan
Noriaki Yahata
Department of Youth Mental Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
Naho Ichikawa
Department of Psychiatry and Neurosciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
Yuki Sakai
Brain Information Communication Research Laboratory Group, Advanced Telecommunications Research Institute International, Kyoto, Japan; Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
Takashi Yamada
Brain Information Communication Research Laboratory Group, Advanced Telecommunications Research Institute International, Kyoto, Japan; Medical Institute of Developmental Disabilities Research, Showa University, Tokyo, Japan
Noriko Matsukawa
Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Go Okada
Department of Psychiatry and Neurosciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
Saori C Tanaka
Brain Information Communication Research Laboratory Group, Advanced Telecommunications Research Institute International, Kyoto, Japan
Kiyoto Kasai
Department of Youth Mental Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Nobumasa Kato
Medical Institute of Developmental Disabilities Research, Showa University, Tokyo, Japan
Yasumasa Okamoto
Department of Psychiatry and Neurosciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
Brain Information Communication Research Laboratory Group, Advanced Telecommunications Research Institute International, Kyoto, Japan; Computational and Biological Learning Laboratory, Department of Engineering, University of Cambridge, Cambridge, United Kingdom; Center for Information and Neural Networks, National Institute of Information and Communications Technology, Osaka, Japan
Hidehiko Takahashi
Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Mitsuo Kawato
Brain Information Communication Research Laboratory Group, Advanced Telecommunications Research Institute International, Kyoto, Japan
Brain Information Communication Research Laboratory Group, Advanced Telecommunications Research Institute International, Kyoto, Japan; Department of Psychology, The University of Tokyo, Tokyo, Japan
Working memory deficits are present in many neuropsychiatric diseases with diagnosis-related severity. However, it is unknown whether this common behavioral abnormality is a continuum explained by a neural mechanism shared across diseases or a set of discrete dysfunctions. Here, we performed predictive modeling to examine working memory ability (WMA) as a function of normative whole-brain connectivity across psychiatric diseases. We built a quantitative model for letter three-back task performance in healthy participants, using resting state functional magnetic resonance imaging (rs-fMRI). This normative model was applied to independent participants (N = 965) including four psychiatric diagnoses. Individual’s predicted WMA significantly correlated with a measured WMA in both healthy population and schizophrenia. Our predicted effect size estimates on WMA impairment were comparable to previous meta-analysis results. These results suggest a general association between brain connectivity and working memory ability applicable commonly to health and psychiatric diseases.
