Microbial biotransformation as a tool for drug development based on natural products from mevalonic acid pathway: A review

Mohamed-Elamir F. Hegazy; Tarik A. Mohamed; Abdelsamed I. ElShamy; Abou-El-Hamd H. Mohamed; Usama A. Mahalel; Eman H. Reda; Alaa M. Shaheen; Wafaa A. Tawfik; Abdelaaty A. Shahat; Khalid A. Shams; Nahla S. Abdel-Azim; Fayza M. Hammouda

doi:10.1016/j.jare.2014.11.009

Journal of Advanced Research (Jan 2015)

Microbial biotransformation as a tool for drug development based on natural products from mevalonic acid pathway: A review

Mohamed-Elamir F. Hegazy,
Tarik A. Mohamed,
Abdelsamed I. ElShamy,
Abou-El-Hamd H. Mohamed,
Usama A. Mahalel,
Eman H. Reda,
Alaa M. Shaheen,
Wafaa A. Tawfik,
Abdelaaty A. Shahat,
Khalid A. Shams,
Nahla S. Abdel-Azim,
Fayza M. Hammouda

Affiliations

Mohamed-Elamir F. Hegazy: Phytochemistry Department and Center of Excellence for Advanced Sciences, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt
Tarik A. Mohamed: Phytochemistry Department, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt
Abdelsamed I. ElShamy: Department of Natural Compounds Chemistry, National Research Centre, Dokki, 12311 Cairo, Egypt
Abou-El-Hamd H. Mohamed: Department of Chemistry, Aswan-Faculty of Science, South Valley University, Aswan, Egypt
Usama A. Mahalel: Department of Botany, Aswan-Faculty of Science, South Valley University, Aswan, Egypt
Eman H. Reda: Phytochemistry Department, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt
Alaa M. Shaheen: Phytochemistry Department, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt
Wafaa A. Tawfik: Phytochemistry Department, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt
Abdelaaty A. Shahat: Phytochemistry Department, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt
Khalid A. Shams: Phytochemistry Department, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt
Nahla S. Abdel-Azim: Phytochemistry Department, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt
Fayza M. Hammouda: Phytochemistry Department, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt

DOI: https://doi.org/10.1016/j.jare.2014.11.009
Journal volume & issue: Vol. 6, no. 1
pp. 17 – 33

Abstract

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Natural products are structurally and biologically interesting metabolites, but they have been isolated in minute amounts. The syntheses of such natural products help in obtaining them in bulk amounts. The recognition of microbial biotransformation as important manufacturing tool has increased in chemical and pharmaceutical industries. In recent years, microbial transformation is increasing significantly from limited interest into highly active area in green chemistry including preparation of pharmaceutical products. This is the first review published on the usage of microbial biocatalysts for some natural product classes and natural product drugs.

Published in Journal of Advanced Research

ISSN: 2090-1232 (Print); 2090-1224 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General); Science: Science (General)
Website: http://www.journals.elsevier.com/journal-of-advanced-research/

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