Leukemia Research Reports (Jan 2015)

Patterns of relapse and outcome of elderly multiple myeloma patients treated as front-line therapy with novel agents combinations

  • Aurelio Lopez,
  • Maria-Victoria Mateos,
  • Albert Oriol,
  • Marta Valero,
  • Joaquín Martínez,
  • Jose Ignacio Lorenzo,
  • Montserrat Perez,
  • Rafael Martinez,
  • Raquel de Paz,
  • Miguel Granell,
  • Felipe De Arriba,
  • M. Jesús Blanchard,
  • Francisco Javier Peñalver,
  • Jose Luis Bello,
  • Maria Luisa Martin,
  • Joan Bargay,
  • Joan Blade,
  • Juan Jose Lahuerta,
  • Jesús F. San Miguel,
  • Javier de la Rubia

DOI
https://doi.org/10.1016/j.lrr.2015.09.002
Journal volume & issue
Vol. 4, no. 2
pp. 64 – 69

Abstract

Read online

We report the characteristics of relapse, treatment response, and outcomes of 145 elderly patients with multiple myeloma in first relapse after front-line treatment with VMP or VTP. Reappearance of CRAB symptoms (113 patients) and more aggressive forms of disease (32 patients) were the most common patterns of relapse. After second-line therapy, 75 (51.7%) patients achieved at partial response and 16 (11%) complete response (CR). Overall survival was longer among patients receiving VMP as front-line induction (21.4 vs. 14.4 months, P=0.037), in patients achieving CR (28.3 vs. 14.8 months; P=0.04), and in patients without aggressive relapse (28.6 vs. 7.6 months; P=0.0007).

Keywords