Krt5+/Krt15+ foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress

Hyeongsun Moon; Jerry Zhu; Leanne R. Donahue; Eunju Choi; Andrew C. White

doi:10.1038/s41467-019-10194-0

Nature Communications (May 2019)

Krt5+/Krt15+ foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress

Hyeongsun Moon,
Jerry Zhu,
Leanne R. Donahue,
Eunju Choi,
Andrew C. White

Affiliations

Hyeongsun Moon: Department of Biomedical Sciences, Cornell University
Jerry Zhu: Department of Biomedical Sciences, Cornell University
Leanne R. Donahue: Department of Biomedical Sciences, Cornell University
Eunju Choi: Department of Pathology, Microbiology and Immunology, University of California Davis
Andrew C. White: Department of Biomedical Sciences, Cornell University

DOI: https://doi.org/10.1038/s41467-019-10194-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

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Cellular extrinsic environmental factors contribute to tumour development. Here, the authors show that gastric acid stress stimulates tumour formation from a defined tumour-competent Krt5 + /Krt15 + foregut basal progenitor cell population.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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