REGULATORY T CELLS AND THEIR ROLE IN RHEUMATIC DISEASES: A POTENTIAL TARGET FOR NOVEL THERAPEUTIC DEVELOPMENT

Diana Milojevic; Khoa D. Nguyen; Diane Wara; Elizabeth D. Mellins

doi:10.37897/RJP.2009.1.11

Romanian Journal of Pediatrics (Mar 2009)

REGULATORY T CELLS AND THEIR ROLE IN RHEUMATIC DISEASES: A POTENTIAL TARGET FOR NOVEL THERAPEUTIC DEVELOPMENT

Diana Milojevic,
Khoa D. Nguyen,
Diane Wara,
Elizabeth D. Mellins

Affiliations

Diana Milojevic: Department of Pediatrics, UCSF, San Francisco, CA 94143, USA
Khoa D. Nguyen: Department of Pediatrics, Stanford University, Stanford, CA 94305, USA
Diane Wara: Department of Pediatrics, UCSF, San Francisco, CA 94143, USA
Elizabeth D. Mellins: Department of Pediatrics, Stanford University, Stanford, CA 94305, USA

DOI: https://doi.org/10.37897/RJP.2009.1.11
Journal volume & issue: Vol. 58, no. 1
pp. 70 – 83

Abstract

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Regulatory T cells have an important role in limiting immune reactions and are essential regulators of selftolerance. Among them, CD4+CD25high regulatory T cells are the best-described subset. In this article, we summarize current knowledge on the phenotype, function, and development of CD4+CD25high regulatory T cells. We also review the literature on the role of these T cells in rheumatic diseases and discuss the potential for their use in immunotherapy

Published in Romanian Journal of Pediatrics

ISSN: 1454-0398 (Print); 2069-6175 (Online)
Publisher: Amaltea Medical Publishing House
Country of publisher: Romania
LCC subjects: Medicine: Pediatrics
Website: https://rjp.com.ro/

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Abstract

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