Associations between night-time sleep duration and fasting glucose and ratio of triglyceride to high-density lipoprotein cholesterol among adults free of type 2 diabetes or without diagnosed type 2 diabetes: a multicentre, cross-sectional study in China
Rong Zhang,
Li Zhang,
Qiang Li,
Minying Zhang,
Feng Liu,
Shuo Chen,
Yu-Jie Niu,
Xin Qi,
Chunjun Li,
Jiangshan He,
Chenglin Hong,
Yuxue Wang,
Yaqi Fan,
Pei Guo,
Binbin Zhang,
Shitao Ma,
Mianzhi Zhang
Affiliations
Rong Zhang
Department of Gynecologic Oncology, Shanghai Geriatric Medical Center, Shanghai, China
Li Zhang
Department of Cardiology, Huzhou Central Hospital, The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, The Affiliated Central Hospital of Huzhou University, Huzhou, Zhejiang, China
Qiang Li
Beijing Physical Examination Center, Beijing, China
Minying Zhang
School of Medicine, Nankai University, Tianjin, China
Feng Liu
Department of Urology, Affiliated Sixth People’s Hospital South Campus, Shanghai Jiao Tong University, Shanghai, China
Shuo Chen
Beijing Physical Examination Center, Beijing, China
Yu-Jie Niu
Hebei Key Laboratory of Environment and Human Health, Shijiazhuang, Hebei, China
Xin Qi
Clinical College of Traditional Chinese Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu, China
Chunjun Li
Tianjin People`s Hospital Tianjin Union Medical Center, Tianjin, China
Jiangshan He
School of Medicine, Nankai University, Tianjin, China
Chenglin Hong
Department of Social Welfare, University of California, Los Angeles, California, USA
Yuxue Wang
School of Medicine, Nankai University, Tianjin, China
Yaqi Fan
School of Medicine, Nankai University, Tianjin, China
Pei Guo
School of Medicine, Nankai University, Tianjin, China
Binbin Zhang
Department of Infectious Diseases and Hepatology, The Affiliated Hospital of Hangzhou Normal University, HangZhou, Zhejiang, China
Shitao Ma
Hebei Key Laboratory of Environment and Human Health, Shijiazhuang, Hebei, China
Mianzhi Zhang
Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China
Objectives We aimed to assess the associations between night-time sleep duration and fasting glucose (FG), triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio and body mass index (BMI) among adults free of type 2 diabetes (T2D) or without diagnosed T2D.Design Cross-sectional study.Setting Medical examination centres at six hospitals in Beijing-Tianjin-Hebei region, China.Participants Participants were recruited via multistage, stratified cluster sampling. We included adults free of T2D or without diagnosed T2D who attended for physical examination and completed the validated questionnaire. 32 497 participants were included in the study, of whom 52.50% were men.Primary and secondary outcome measures FG, TG, HDL-C, height and weight were measured.Results Overall, 12.80% and 9.67% reported night sleep duration <7 hours and ≥9 hours, respectively; 6.91% had elevated FG and 3.57% had undiagnosed T2D. Sleep duration had an independent, U-shaped associated with FG (β1 (linear term)=−0.111, p=0.047; β2 (quadratic term)=0.008, p=0.026) with 6.9 hours of sleep associated with the lowest FG and a negative association with BMI (β=−0.154, p<0.001). BMI mediated a U-shaped association of sleep duration with TG/HDL-C (β1=−0.040, p=0.017; β2=0.003, p=0.023).Conclusions Both short and long night-time sleep was associated with elevated FG, and short sleep duration was associated with increased BMI. BMI mediated a U-shaped association between sleep duration and TG/HDL-C.
