Journal of Materials Research and Technology (Jan 2023)

Integrated porous polyetheretherketone implants for treating skull defect

  • Mingguang Zhang,
  • Mei-li Qi,
  • Kunshan Yuan,
  • Hanjie Liu,
  • Jinping Ren,
  • Aihua Liu,
  • Shengkun Yao,
  • Xiangrui Guo,
  • Xiushan Li,
  • Haijun Zhang

Journal volume & issue
Vol. 22
pp. 728 – 734

Abstract

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Skull defect is a common clinical disease, and the corresponding treatment is still a grand challenge. No artificial product can perfectly integrate with human skull and match the skull defect during growth. Herein, we report a porous polyetheretherketone (PEEK) implant with the microstructures almost identical to natural bones for repairing skull defect. Compared to non-porous PEEK controls, the porous PEEK implants efficiently promote cell adhesion, regenerate skull tissues, and finally achieve perfect healing with surrounding tissues within 6 months. This work suggests the important potential of integrated porous PEEK implants for treating skull defect in clinic, especially for children with rapidly growing skulls.

Keywords