Structural insights into the elevator-type transport mechanism of a bacterial ZIP metal transporter

Yao Zhang; Yuhan Jiang; Kaifu Gao; Dexin Sui; Peixuan Yu; Min Su; Guo-Wei Wei; Jian Hu

doi:10.1038/s41467-023-36048-4

Nature Communications (Jan 2023)

Structural insights into the elevator-type transport mechanism of a bacterial ZIP metal transporter

Yao Zhang,
Yuhan Jiang,
Kaifu Gao,
Dexin Sui,
Peixuan Yu,
Min Su,
Guo-Wei Wei,
Jian Hu

Affiliations

Yao Zhang: Department of Biochemistry and Molecular Biology, Michigan State University
Yuhan Jiang: Department of Chemistry, Michigan State University
Kaifu Gao: Department of Mathematics, Michigan State University
Dexin Sui: Department of Biochemistry and Molecular Biology, Michigan State University
Peixuan Yu: Department of Biochemistry and Molecular Biology, Michigan State University
Min Su: Life Sciences Institute, University of Michigan
Guo-Wei Wei: Department of Biochemistry and Molecular Biology, Michigan State University
Jian Hu: Department of Biochemistry and Molecular Biology, Michigan State University

DOI: https://doi.org/10.1038/s41467-023-36048-4
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 14

Abstract

Read online

The ZIP family (SLC39A) is involved in transition metal homeostasis. Here, authors use integrated approaches to conclude that the ZIP from Bordetella bronchiseptica (BbZIP) utilizes the elevator-type transport mechanism to achieve alternating access.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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