Near quantitative synthesis of urea macrocycles enabled by bulky N-substituent

Yingfeng Yang; Hanze Ying; Zhixia Li; Jiang Wang; Yingying Chen; Binbin Luo; Danielle L. Gray; Andrew Ferguson; Qian Chen; Y. Z; Jianjun Cheng

doi:10.1038/s41467-021-21678-3

Nature Communications (Mar 2021)

Near quantitative synthesis of urea macrocycles enabled by bulky N-substituent

Yingfeng Yang,
Hanze Ying,
Zhixia Li,
Jiang Wang,
Yingying Chen,
Binbin Luo,
Danielle L. Gray,
Andrew Ferguson,
Qian Chen,
Y. Z,
Jianjun Cheng

Affiliations

Yingfeng Yang: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign
Hanze Ying: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign
Zhixia Li: Department of Nuclear, Plasma, and Radiological Engineering, University of Illinois at Urbana-Champaign
Jiang Wang: Department of Chemistry, Rice University
Yingying Chen: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign
Binbin Luo: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign
Danielle L. Gray: George L. Clark X-Ray Facility & 3M Materials Laboratory, School of Chemical Sciences, University of Illinois at Urbana-Champaign
Andrew Ferguson: Pritzker School of Molecular Engineering, University of Chicago
Qian Chen: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign
Y. Z: Department of Nuclear, Plasma, and Radiological Engineering, University of Illinois at Urbana-Champaign
Jianjun Cheng: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign

DOI: https://doi.org/10.1038/s41467-021-21678-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 10

Abstract

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Macrocycles are molecular structures extensively used in the design of catalysts, therapeutics and supramolecular assemblies but synthesis procedures that can produce macrocycles in high yield under high reaction concentrations are rare. Here the authors report the use of dynamic hindered urea bond for the construction of urea macrocycles with high efficiency.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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