Relationships between brain structure-function coupling in normal aging and cognition: A cross-ethnicity population-based study
Chang Liu,
Jing Jing,
Jiyang Jiang,
Wei Wen,
Wanlin Zhu,
Zixiao Li,
Yuesong Pan,
Xueli Cai,
Hao Liu,
Yijun Zhou,
Xia Meng,
Jicong Zhang,
Yilong Wang,
Hao Li,
Yong Jiang,
Huaguang Zheng,
Suying Wang,
Haijun Niu,
Nicole Kochan,
Henry Brodaty,
Tiemin Wei,
Perminder Sachdev,
Tao Liu,
Yongjun Wang
Affiliations
Chang Liu
Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China
Jing Jing
China National Clinical Research Center for Neurological Diseases, Beijing, China; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Corresponding authors.
Jiyang Jiang
Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, Australia
Wei Wen
Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, Australia; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, UNSW Medicine, Sydney NSW 2052, Australia
Wanlin Zhu
China National Clinical Research Center for Neurological Diseases, Beijing, China; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Zixiao Li
China National Clinical Research Center for Neurological Diseases, Beijing, China; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Yuesong Pan
China National Clinical Research Center for Neurological Diseases, Beijing, China; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Xueli Cai
Department of Neurology, Lishui Hospital, Zhejiang University School of Medicine, Lishui, Zhejiang, China
Hao Liu
Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China
Yijun Zhou
Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China
Xia Meng
China National Clinical Research Center for Neurological Diseases, Beijing, China; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Jicong Zhang
Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China; Corresponding authors.
Yilong Wang
China National Clinical Research Center for Neurological Diseases, Beijing, China; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Hao Li
China National Clinical Research Center for Neurological Diseases, Beijing, China
Yong Jiang
China National Clinical Research Center for Neurological Diseases, Beijing, China; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Huaguang Zheng
China National Clinical Research Center for Neurological Diseases, Beijing, China; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Suying Wang
Cerebrovascular Research Lab, Lishui Hospital, Zhejiang University School of Medicine, Lishui, Zhejiang, China
Haijun Niu
Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China
Nicole Kochan
Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, Australia; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, UNSW Medicine, Sydney NSW 2052, Australia
Henry Brodaty
Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, Australia; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, UNSW Medicine, Sydney NSW 2052, Australia
Tiemin Wei
Department of Cardiology, Lishui Hospital, Zhejiang University School of Medicine, Lishui, Zhejiang, China
Perminder Sachdev
Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, Australia; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, UNSW Medicine, Sydney NSW 2052, Australia
Tao Liu
Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China; Corresponding authors.
Yongjun Wang
China National Clinical Research Center for Neurological Diseases, Beijing, China; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Corresponding authors.
Increased efforts in neuroscience seek to understand how macro-anatomical and physiological connectomes cooperatively work to generate cognitive behaviors. However, the structure-function coupling characteristics in normal aging individuals remain unclear. Here, we developed an index, the Coupling in Brain Structural connectome and Functional connectome (C-BSF) index, to quantify regional structure-function coupling in a large community-based cohort. C-BSF used diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (fMRI) data from the Polyvascular Evaluation for Cognitive Impairment and Vascular Events study (PRECISE) cohort (2007 individuals, age: 61.15 ± 6.49 years) and the Sydney Memory and Ageing Study (MAS) cohort (254 individuals, age: 83.45 ± 4.33 years). We observed that structure-function coupling was the strongest in the visual network and the weakest in the ventral attention network. We also observed that the weaker structure-function coupling was associated with increased age and worse cognitive level of the participant. Meanwhile, the structure-function coupling in the visual network was associated with the visuospatial performance and partially mediated the connections between age and the visuospatial function. This work contributes to our understanding of the underlying brain mechanisms by which aging affects cognition and also help establish early diagnosis and treatment approaches for neurological diseases in the elderly.
