Nature Communications (Mar 2020)
Transcriptomic evidence that von Economo neurons are regionally specialized extratelencephalic-projecting excitatory neurons
- Rebecca D. Hodge,
- Jeremy A. Miller,
- Mark Novotny,
- Brian E. Kalmbach,
- Jonathan T. Ting,
- Trygve E. Bakken,
- Brian D. Aevermann,
- Eliza R. Barkan,
- Madeline L. Berkowitz-Cerasano,
- Charles Cobbs,
- Francisco Diez-Fuertes,
- Song-Lin Ding,
- Jamison McCorrison,
- Nicholas J. Schork,
- Soraya I. Shehata,
- Kimberly A. Smith,
- Susan M. Sunkin,
- Danny N. Tran,
- Pratap Venepally,
- Anna Marie Yanny,
- Frank J. Steemers,
- John W. Phillips,
- Amy Bernard,
- Christof Koch,
- Roger S. Lasken,
- Richard H. Scheuermann,
- Ed S. Lein
Affiliations
- Rebecca D. Hodge
- Allen Institute for Brain Science
- Jeremy A. Miller
- Allen Institute for Brain Science
- Mark Novotny
- J. Craig Venter Institute
- Brian E. Kalmbach
- Allen Institute for Brain Science
- Jonathan T. Ting
- Allen Institute for Brain Science
- Trygve E. Bakken
- Allen Institute for Brain Science
- Brian D. Aevermann
- J. Craig Venter Institute
- Eliza R. Barkan
- Allen Institute for Brain Science
- Madeline L. Berkowitz-Cerasano
- Department of Neurological Surgery, University of Washington
- Charles Cobbs
- The Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute
- Francisco Diez-Fuertes
- J. Craig Venter Institute
- Song-Lin Ding
- Allen Institute for Brain Science
- Jamison McCorrison
- J. Craig Venter Institute
- Nicholas J. Schork
- J. Craig Venter Institute
- Soraya I. Shehata
- Allen Institute for Brain Science
- Kimberly A. Smith
- Allen Institute for Brain Science
- Susan M. Sunkin
- Allen Institute for Brain Science
- Danny N. Tran
- J. Craig Venter Institute
- Pratap Venepally
- J. Craig Venter Institute
- Anna Marie Yanny
- Allen Institute for Brain Science
- Frank J. Steemers
- Illumina, Inc.
- John W. Phillips
- Allen Institute for Brain Science
- Amy Bernard
- Allen Institute for Brain Science
- Christof Koch
- Allen Institute for Brain Science
- Roger S. Lasken
- J. Craig Venter Institute
- Richard H. Scheuermann
- J. Craig Venter Institute
- Ed S. Lein
- Allen Institute for Brain Science
- DOI
- https://doi.org/10.1038/s41467-020-14952-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Little is known about von Economo neurons, which have been described in a subset of mammals and appear to be selectively lost in several human neurological diseases. Here, authors reveal the gene expression profile of these cells and show that they are likely long-distance projection neurons.
