Cancer Management and Research (Oct 2020)
Matrilysins and Stromelysins in Pathogenesis and Diagnostics of Cancers
Abstract
Barbara Maria Piskór,1 Andrzej Przylipiak,1 Emilia Dąbrowska,1 Marek Niczyporuk,1 Sławomir Ławicki2 1Department of Aesthetic Medicine, Medical University of Bialystok, Bialystok, Poland; 2Department of Population Medicine and Civilization Diseases Prevention, Medical University of Bialystok, Bialystok, PolandCorrespondence: Barbara Maria PiskórDepartment of Aesthetic Medicine, Medical University of Bialystok, Akademicka 3, Bialystok 15-267, PolandTel +48 85748 5822Email [email protected]: Matrix metalloproteinases (MMPs) are endopeptidases which are widely studied in terms of their role in the physiological and pathological processes in the organism. In this article, we consider usefulness of matrilysins and stromelysins in pathogenesis and diagnostic of the most common malignancies in the world, e.g., lung, breast, prostate, and colorectal cancers. In all of the mentioned cancers, matrilysins and stromelysins have a pivotal role in their development and also may have diagnostic utility. Influence to the cancerous process is connected with specific dependencies between these enzymes and components of the extracellular matrix (ECM), non-matrix components like cell surface components. All the information provided below allows to take a closer look at matrilysins and stromelysins and their functions in the cancer development.Keywords: metalloproteinases, matrilysin-1, matrilysin-2, stromelysin-1, stromelysin-2
