Gender Differences in the Level of Antibodies to Measles Virus in Adults
P. Mikhail Kostinov,
I. Pavel Zhuravlev,
N. Nikolay Filatov,
M. Аristitsa Kostinova,
B. Valentina Polishchuk,
D. Anna Shmitko,
V. Cyrill Mashilov,
E. Anna Vlasenko,
A. Alexey Ryzhov,
M. Аnton Kostinov
Affiliations
P. Mikhail Kostinov
Federal State Budgetary Scientific Institution I.I. Mechnikov Research Institute of Vaccines and Sera, Maliyi Kazenniy Pereulok, 5a, 105064 Moscow, Russia
I. Pavel Zhuravlev
Federal State Budgetary Scientific Institution I.I. Mechnikov Research Institute of Vaccines and Sera, Maliyi Kazenniy Pereulok, 5a, 105064 Moscow, Russia
N. Nikolay Filatov
Federal State Budgetary Scientific Institution I.I. Mechnikov Research Institute of Vaccines and Sera, Maliyi Kazenniy Pereulok, 5a, 105064 Moscow, Russia
M. Аristitsa Kostinova
National Research Center Institute of Immunology Federal Medical-Biological Agency of Russia, Kashirskoe Shosse, 24, 115478 Moscow, Russia
B. Valentina Polishchuk
Federal State Budgetary Scientific Institution I.I. Mechnikov Research Institute of Vaccines and Sera, Maliyi Kazenniy Pereulok, 5a, 105064 Moscow, Russia
D. Anna Shmitko
Federal State Budgetary Scientific Institution I.I. Mechnikov Research Institute of Vaccines and Sera, Maliyi Kazenniy Pereulok, 5a, 105064 Moscow, Russia
V. Cyrill Mashilov
Federal State Budgetary Scientific Institution I.I. Mechnikov Research Institute of Vaccines and Sera, Maliyi Kazenniy Pereulok, 5a, 105064 Moscow, Russia
E. Anna Vlasenko
Novokuznetsk State Institute for Advanced Training of Physicians, Branch Campus of the Russian Medical Academy of Continuous Professional Education, Prospect Stroiteley, 5, 654005 Novokuznetsk, Russia
A. Alexey Ryzhov
Federal State Budgetary Scientific Institution I.I. Mechnikov Research Institute of Vaccines and Sera, Maliyi Kazenniy Pereulok, 5a, 105064 Moscow, Russia
M. Аnton Kostinov
Federal State Budgetary Scientific Institution I.I. Mechnikov Research Institute of Vaccines and Sera, Maliyi Kazenniy Pereulok, 5a, 105064 Moscow, Russia
Individuals without a protective antibody level are susceptible to measles infection. There are differences in the persistence of antibodies after vaccination and infection, while the impact of gender on this process has not been sufficiently studied. Measles Ig G antibodies were measured in 1742 employees of a large hospital facility—403 men and 1339 women aged from 25 to 67 years; 15% participants had antibody levels less than the protective threshold of ≥0.18 IU/mL. Significant differences were found in the age group 40–49, where the level of IgG antibodies to measles among men was higher than among women (1.51 IU/mL (0.41; 3.38) vs. 0.70 IU/mL (0.22;1.98) respectively, (U = 3.2, p = 0,001)); in the age group 60 and older, by contrast, the level of antibodies among women was higher compared to men (3.29 IU/mL (1.72; 4.07) vs. 2.90 IU/mL (1.46; 3.53) respectively (U = 2.2, p = 0.03)). The proportion of seronegative women in the age group 40–49 was significantly higher than of seronegative men: 22 [18–26]% and 11 [6–18]% respectively (χ2 = 7.0, p = 0.001). The revealed gender characteristics that affect persistence of measles immunity may be important in personalization of vaccinal prevention for men and women.
