Clinical and social efficiency of therapy of acute lymphoblastic leukemia among children from 1993 to 2011 in Omsk Region

Abstract

The purpose of our research was the estimation of results of treatment of childhood acute lymphoblastic leukemia in Omskregion from 1993 to 2011. 173 children with acute lymphoblastic leukemia were included in research for an estimation of clinical efficiency and 32 children for research of quality of a life. The Kaplan—Meier method was used to estimate survival rates: overall survival was (71.0 ± 3.9)%, event free survival (66.2 ± 4.0)% and disease-free survival (75.0 ± 4.1)%. Parameters of quality of a life defined by means of questionnaire PEDQL 4.0 GCS: quality of a life at children of 8—12 years is lowered at estimation by parents and at children of 13—18 years at a self-estimation.

Keywords

• острый лимфобластный лейкоз
• дети
• протокол all-bfm-90m/95
• выживаемость
• качество жизни