Nature Communications (Jan 2020)

Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes

  • Marco D. Carpenter,
  • Qiwen Hu,
  • Allison M. Bond,
  • Sonia I. Lombroso,
  • Kyle S. Czarnecki,
  • Carissa J. Lim,
  • Hongjun Song,
  • Mathieu E. Wimmer,
  • R. Christopher Pierce,
  • Elizabeth A. Heller

DOI
https://doi.org/10.1038/s41467-020-14331-y
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

Read online

The regulation of gene expression underlies many forms of learning and behaviour in the mammalian brain. Carpenter et al. define a molecular mechanism whereby Nr4a1 activation leads to persistent changes in gene expression, chromatin and behaviour, in the context of cocaine abstinence.