Nature Communications (Sep 2017)
RNA localization is a key determinant of neurite-enriched proteome
- Alessandra Zappulo,
- David van den Bruck,
- Camilla Ciolli Mattioli,
- Vedran Franke,
- Koshi Imami,
- Erik McShane,
- Mireia Moreno-Estelles,
- Lorenzo Calviello,
- Andrei Filipchyk,
- Esteban Peguero-Sanchez,
- Thomas Müller,
- Andrew Woehler,
- Carmen Birchmeier,
- Enrique Merino,
- Nikolaus Rajewsky,
- Uwe Ohler,
- Esteban O. Mazzoni,
- Matthias Selbach,
- Altuna Akalin,
- Marina Chekulaeva
Affiliations
- Alessandra Zappulo
- Non-coding RNAs and Mechanisms of Cytoplasmic Gene Regulation, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine
- David van den Bruck
- Non-coding RNAs and Mechanisms of Cytoplasmic Gene Regulation, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine
- Camilla Ciolli Mattioli
- Non-coding RNAs and Mechanisms of Cytoplasmic Gene Regulation, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine
- Vedran Franke
- BIMSB Bioinformatics Platform, Max Delbrück Center for Molecular Medicine
- Koshi Imami
- Proteome Dynamics, Max Delbrück Center for Molecular Medicine
- Erik McShane
- Proteome Dynamics, Max Delbrück Center for Molecular Medicine
- Mireia Moreno-Estelles
- Department of Biology, New York University
- Lorenzo Calviello
- Computational Regulatory Genomics, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine
- Andrei Filipchyk
- Systems Biology of Gene Regulatory Elements, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine
- Esteban Peguero-Sanchez
- Non-coding RNAs and Mechanisms of Cytoplasmic Gene Regulation, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine
- Thomas Müller
- Developmental Biology/Signal Transduction, Max Delbrück Center for Molecular Medicine
- Andrew Woehler
- BIMSB Light Microscopy Platform, Max Delbrück Center for Molecular Medicine
- Carmen Birchmeier
- Developmental Biology/Signal Transduction, Max Delbrück Center for Molecular Medicine
- Enrique Merino
- Departamento de Microbiología Molecular, Instituto de Biotecnología, UNAM, Av. Universidad 2001
- Nikolaus Rajewsky
- Systems Biology of Gene Regulatory Elements, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine
- Uwe Ohler
- Computational Regulatory Genomics, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine
- Esteban O. Mazzoni
- Department of Biology, New York University
- Matthias Selbach
- Proteome Dynamics, Max Delbrück Center for Molecular Medicine
- Altuna Akalin
- BIMSB Bioinformatics Platform, Max Delbrück Center for Molecular Medicine
- Marina Chekulaeva
- Non-coding RNAs and Mechanisms of Cytoplasmic Gene Regulation, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine
- DOI
- https://doi.org/10.1038/s41467-017-00690-6
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Subcellular localization of RNAs and proteins is important for polarized cells such as neurons. Here the authors differentiate mouse embryonic stem cells into neurons, and analyze the local transcriptome, proteome, and translated transcriptome in their cell bodies and neurites, providing a unique resource for future studies on neuronal polarity.
