Nature Communications (Dec 2021)

Metabolic drug survey highlights cancer cell dependencies and vulnerabilities

  • Tea Pemovska,
  • Johannes W. Bigenzahn,
  • Ismet Srndic,
  • Alexander Lercher,
  • Andreas Bergthaler,
  • Adrián César-Razquin,
  • Felix Kartnig,
  • Christoph Kornauth,
  • Peter Valent,
  • Philipp B. Staber,
  • Giulio Superti-Furga

DOI
https://doi.org/10.1038/s41467-021-27329-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 19

Abstract

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Metabolic reprogramming contributes to cancer development and progression. Here, the authors show the utility of a metabolic drug library to uncover metabolic vulnerabilities and obtain functional insights into myeloid leukemia biology.