HISTOLOGICAL CHANGES IN THE PARIETAL CORTEX AND HIPPOCAMPUS OF RATS AFTER INCOMPLETE CEREBRAL ISCHEMIA

Abstract

Background. Cerebrovascular diseases, including stroke, take a leading position in the structure of morbidity and mortality worldwide. Solving the problem of stroke requires an in-depth study of its pathogenesis, for which it is necessary to identify morphofunctional changes in the brain at the cellular, subcellular and molecular levels. Purpose: To study histological disorders of neurons in parietal cortex and hippocampus of rats after incomplete cerebral ischemia. Material and methods. The experiments were performed on female white rats weighing 230 ± 20 g. The use of rats as experimental animals was due to the similarity of angio-architectonics and morphology of the cerebral cortex in rats and humans. Incomplete cerebral ischemia was modeled by ligation of both common carotid arteries under intravenous thiopental anesthesia (40-50 mg / kg). Results. Incomplete cerebral ischemia leads to histological changes in the neurons of the parietal cortex and hippocampus. There is a decrease in the number of normochromic and an increase in the number of pathological forms of neurons, their size and shape change significantly. Conclusions. Incomplete ischemia of the brain leads to significant histological changes in the neurons of the parietal cortex and hippocampus of rats. The disorders are similar, but they are more pronounced in the parietal cortex, the neurons of which are more sensitive to lack of oxygen.

Keywords

• histological changes
• parietal cortex
• hippocampus
• ischemia