Comparing the Effectiveness Results of Heparin and Enoxaparin after Total Hip Artroplasty

Abstract

Background: One of the most important complications of immobilization is deep vein thrombosis (DVT), especially in lower extremities, and major surgeries, especially orthopaedic surgery. The aim of this study was comparing the effectiveness of heparin among short-time (10 days) and long-time (20 days) enoxaparine administration to introdue more suitable preventive method. Methods: In a prospective study, 120 patients underwent hip arthroplasty enrolled in three groups; group I recieved 5000 IU heparin three times daily (ter die sumendum or TDS), Group II recieved 40 mg enoxaparine daily for 10 days, and Group III received 40 mg enoxaparine daily for 20 days. After data collection by check list, the ANOVA and χ2 tests were used for analysis. P-value less than 0.05 was considered significant. Findings: Incidence of deep vein thrombosis in group III was reduced more than group I after hip replacement surgery. Also, pulmonary thromboembolism (PTE) was reduced in group III more than group II. PTE and postoperative death were not significantly different among enoxaparin and heparin groups. Conclusion: Enoxaparin is more effective than standard heparin in reducing pulmonary thromboembolism and deep vein thrombosis.

Keywords

• Deep vein thrombosis (DVT)
• Pulmonary thrombo embolism (PTE)
• Heparin
• Enoxaparin