Induced Pluripotent Stem Cell-Derived Neural Cells Survive and Mature in the Nonhuman Primate Brain
Marina E. Emborg,
Yan Liu,
Jiajie Xi,
Xiaoqing Zhang,
Yingnan Yin,
Jianfeng Lu,
Valerie Joers,
Christine Swanson,
James E. Holden,
Su-Chun Zhang
Affiliations
Marina E. Emborg
Preclinical Parkinson’s Research Program, Wisconsin National Primate Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
Yan Liu
Waisman Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
Jiajie Xi
Waisman Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
Xiaoqing Zhang
Waisman Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
Yingnan Yin
Waisman Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
Jianfeng Lu
Waisman Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
Valerie Joers
Preclinical Parkinson’s Research Program, Wisconsin National Primate Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
Christine Swanson
Preclinical Parkinson’s Research Program, Wisconsin National Primate Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
James E. Holden
Preclinical Parkinson’s Research Program, Wisconsin National Primate Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
Su-Chun Zhang
Waisman Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
The generation of induced pluripotent stem cells (iPSCs) opens up the possibility for personalized cell therapy. Here, we show that transplanted autologous rhesus monkey iPSC-derived neural progenitors survive for up to 6 months and differentiate into neurons, astrocytes, and myelinating oligodendrocytes in the brains of MPTP-induced hemiparkinsonian rhesus monkeys with a minimal presence of inflammatory cells and reactive glia. This finding represents a significant step toward personalized regenerative therapies.
