Journal of Applied Pharmaceutical Research (Dec 2014)

Development and characterization of surface solid dispersion of curcumin for solubility enhancement

  • Mahendra Vikram Singh,
  • Divya Juyal,
  • Vikram Singh,
  • Geeta Rawat,
  • Akhilesh Tiwari

Journal volume & issue
Vol. 2, no. 4
pp. 17 – 23

Abstract

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Surface solid dispersion (SSD) of curcumin was developed and characterized with purview to overcome solubility hurdle in its pharmacokinetic and pharmacodynamic performance. SSDs were prepared by co-evaporation method using polyplasdone XL, croscarmelose sodium, and silicone dioxide and polyethlene glycol 6000 as carrier. The optimized SSD (F9) was characterized using FE-SEM and XRD as an analytical tool. The formulation of modified Curcumin shows better drug release profile as compared to the natural Curcumin. Formulation F9 released more than 90% of the loaded Curcumin within 30 minutes where marketed formulations shows 90% drug only after 60 minutes.