Nature Communications (Feb 2018)
Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone
- Xiao-Feng Li,
- Hao-Long Dong,
- Hong-Jiang Wang,
- Xing-Yao Huang,
- Ye-Feng Qiu,
- Xue Ji,
- Qing Ye,
- Chunfeng Li,
- Yang Liu,
- Yong-Qiang Deng,
- Tao Jiang,
- Gong Cheng,
- Fu-Chun Zhang,
- Andrew D. Davidson,
- Ya-Jun Song,
- Pei-Yong Shi,
- Cheng-Feng Qin
Affiliations
- Xiao-Feng Li
- State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
- Hao-Long Dong
- State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
- Hong-Jiang Wang
- State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
- Xing-Yao Huang
- State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
- Ye-Feng Qiu
- Laboratory Animal Center, Academy of Military Medical Science
- Xue Ji
- State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
- Qing Ye
- State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
- Chunfeng Li
- State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
- Yang Liu
- Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University
- Yong-Qiang Deng
- State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
- Tao Jiang
- State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
- Gong Cheng
- Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University
- Fu-Chun Zhang
- Guangzhou Eighth People’s Hospital, Guangzhou Medical University
- Andrew D. Davidson
- Faculty of Biomedical Sciences, School of Cellular and Molecular Medicine, University of Bristol
- Ya-Jun Song
- State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
- Pei-Yong Shi
- Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch
- Cheng-Feng Qin
- State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
- DOI
- https://doi.org/10.1038/s41467-018-02975-w
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Given the recent Zika virus (ZIKV) epidemic, development of an effective vaccine is of high importance. Here, the authors use a licensed live-attenuated flavivirus vaccine backbone to develop a ZIKV vaccine and determine immunogenicity, safety and protection profiles in different animal models.
