Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling

Linh T. Vuong; Carlo Iomini; Sophie Balmer; Davide Esposito; Stuart A. Aaronson; Marek Mlodzik

doi:10.1038/s41467-018-07605-z

Nature Communications (Dec 2018)

Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling

Linh T. Vuong,
Carlo Iomini,
Sophie Balmer,
Davide Esposito,
Stuart A. Aaronson,
Marek Mlodzik

Affiliations

Linh T. Vuong: Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai
Carlo Iomini: Department of Ophthalmology, Icahn School of Medicine at Mount Sinai
Sophie Balmer: Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai
Davide Esposito: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Stuart A. Aaronson: Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai
Marek Mlodzik: Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai

DOI: https://doi.org/10.1038/s41467-018-07605-z
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 16

Abstract

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IFT-A proteins and Kinesin-2 modulate canonical Wnt/Wg-signalling independent of their ciliary role, but how is unclear. Here, the authors show that Kinesin-2 and IFT-A act as a complex to promote nuclear translocation of β-catenin in Drosophila and mouse MEF Wnt signalling independent of its ciliary role.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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