Which outcomes should be used in future bronchiolitis trials? Developing a bronchiolitis core outcome set using a systematic review, Delphi survey and a consensus workshop
Matthew Peak,
Ricardo M Fernandes,
Kerry Woolfall,
David Lacy,
Emma Bedson,
Mark David Lyttle,
Paula R Williamson,
Paul S McNamara,
Ashley P Jones,
Vanessa Compton,
Clare van Miert,
Kentigern Thorburn,
A Rosala-Hallas
Affiliations
Matthew Peak
6 Cheshire and Merseyside Medicines for Children Research Network, Alder Hey Children’s NHS Foundation Trust, Liverpool, UK
Ricardo M Fernandes
Department of Pediatrics, Hospital de Santa Maria, Lisboa, Portugal
Kerry Woolfall
Institute of Population, Health and Society, University of Liverpool, Liverpool, Merseyside, UK
David Lacy
Department of Paediatrics, Wirral University Teaching Hospital NHS Foundation Trust, Wirral, Merseyside, UK
Emma Bedson
5 Liverpool Clinical Trials Centre, University of Liverpool, Liverpool, UK
Mark David Lyttle
Faculty of Health and Applied Science, University of the West of England, Bristol, UK
Paula R Williamson
18 University of Liverpool, Liverpool, UK
Paul S McNamara
Institute in the Park, Alder Hey Children’s Hospital, University of Liverpool, Liverpool, Merseyside, UK
Ashley P Jones
9 Liverpool Clinical Trials Centre (LCTC), University of Liverpool, Liverpool, UK
Vanessa Compton
Paediatric Intensive Care Unit, Alder Hey Children`s NHS Foundation Trust, Liverpool, Merseyside, UK
Clare van Miert
School of Nursing and Allied Health, Liverpool John Moores University, Liverpool, Merseyside, UK
Kentigern Thorburn
Paediatric Intensive Care Unit, Alder Hey Children`s NHS Foundation Trust, Liverpool, Merseyside, UK
A Rosala-Hallas
Liverpool Clinical Trials Centre, University of Liverpool, Liverpool, Merseyside, UK
Objectives The objective of this study was to develop a core outcome set (COS) for use in future clinical trials in bronchiolitis. We wanted to find out which outcomes are important to healthcare professionals (HCPs) and to parents and which outcomes should be prioritised for use in future clinical trials.Design and setting The study used a systematic review, workshops and interviews, a Delphi survey and a final consensus workshop.Results Thirteen parents and 45 HCPs took part in 5 workshops; 15 other parents were also separately interviewed. Fifty-six items were identified from the systematic review, workshops and interviews. Rounds one and two of the Delphi survey involved 299 and 194 participants, respectively. Sixteen outcomes met the criteria for inclusion within the COS. The consensus meeting was attended by 10 participants, with representation from all three stakeholder groups. Nine outcomes were added, totalling 25 outcomes to be included in the COS.Conclusion We have developed the first parent and HCP consensus on a COS for bronchiolitis in a hospital setting. The use of this COS will ensure outcomes in future bronchiolitis trials are important and relevant, and will enable the trial results to be compared and combined.Trial registration number ISRCTN75766048.
