Frontiers in Endocrinology (Jun 2024)

Possible involvement of sialidase and sialyltransferase activities in a stage-dependent recycling of sialic acid in some organs of type 1 and type 2 diabetic rats

  • Osas Graham Erhabor,
  • Peter Obochi,
  • Murtala Bindawa Isah,
  • Mohammed Aliyu Usman,
  • Ismaila Alhaji Umar,
  • Mthokozisi B. C. Simelane,
  • Mohammed Nasir Shuaibu,
  • Md. Shahidul Islam,
  • Mohammed Auwal Ibrahim

DOI
https://doi.org/10.3389/fendo.2024.1289653
Journal volume & issue
Vol. 15

Abstract

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BackgroundType 1 (T1D) and type 2 (T2D) diabetes lead to an aberrant metabolism of sialoglycoconjugates and elevated free serum sialic acid (FSSA) level. The present study evaluated sialidase and sialyltranferase activities in serum and some organs relevant to diabetes at early and late stages of T1D and T2D.MethodsSialic acid level with sialidase and sialyltransferase activities were monitored in the serum, liver, pancreas, skeletal muscle and kidney of diabetic animals at early and late stages of the diseases.ResultsThe FSSA and activity of sialidase in the serum were significantly increased at late stage of both T1D and T2D while sialic acid level in the liver was significantly decreased in the early and late stages of T1D and T2D, respectively. Furthermore, the activity of sialidase was significantly elevated in most of the diabetes-relevant organs while the activity of sialyltransferase remained largely unchanged. A multiple regression analysis revealed the contribution of the liver to the FSSA while pancreas and kidney contributed to the activity of sialidase in the serum.ConclusionsWe concluded that the release of hepatic sialic acid in addition to pancreatic and renal sialidase might (in)directly contribute to the increased FSSA during both types of diabetes mellitus.

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