Integrating subvolume dose and myocardial perfusion imaging parameters to assess the impact of radiation therapy on heart function in breast cancer patients: A comparative analysis between left‐ and right‐sided breast cancer

Shan‐Ying Wang; Wei‐Ta Tsai; Kuan‐Heng Lin; Chih‐Wei Yu; Shu‐Ya Yang; Pei‐Wei Shueng; Yen‐Wen Wu; Chen‐Xiong Hsu; Tung‐Hsin Wu

doi:10.1111/1759-7714.15056

Thoracic Cancer (Sep 2023)

Integrating subvolume dose and myocardial perfusion imaging parameters to assess the impact of radiation therapy on heart function in breast cancer patients: A comparative analysis between left‐ and right‐sided breast cancer

Shan‐Ying Wang,
Wei‐Ta Tsai,
Kuan‐Heng Lin,
Chih‐Wei Yu,
Shu‐Ya Yang,
Pei‐Wei Shueng,
Yen‐Wen Wu,
Chen‐Xiong Hsu,
Tung‐Hsin Wu

Affiliations

Shan‐Ying Wang: Department of Biomedical Imaging and Radiological Sciences National Yang Ming Chiao Tung University Taipei Taiwan
Wei‐Ta Tsai: Department of Biomedical Imaging and Radiological Sciences National Yang Ming Chiao Tung University Taipei Taiwan
Kuan‐Heng Lin: Department of Biomedical Imaging and Radiological Sciences National Yang Ming Chiao Tung University Taipei Taiwan
Chih‐Wei Yu: Department of Radiation Oncology China Medical University Hsinchu Hospital Zhubei City Taiwan
Shu‐Ya Yang: Department of Nuclear Medicine Cheng Hsin General Hospital Taipei Taiwan
Pei‐Wei Shueng: Division of Radiation Oncology, Department of Radiology Far Eastern Memorial Hospital New Taipei City Taiwan
Yen‐Wen Wu: Department of Nuclear Medicine Far Eastern Memorial Hospital New Taipei City Taiwan
Chen‐Xiong Hsu: Department of Biomedical Imaging and Radiological Sciences National Yang Ming Chiao Tung University Taipei Taiwan
Tung‐Hsin Wu: Department of Biomedical Imaging and Radiological Sciences National Yang Ming Chiao Tung University Taipei Taiwan

DOI: https://doi.org/10.1111/1759-7714.15056
Journal volume & issue: Vol. 14, no. 26
pp. 2696 – 2706

Abstract

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Abstract Background This study aimed to utilize an innovative method of integrating the 20 subvolume dose of left ventricle and the Tl‐201 single photon emission computed tomography (SPECT) with myocardial perfusion imaging (MPI) parameters in patients with left‐ and right‐sided breast cancer after radiation therapy. Methods Female patients with breast cancer underwent SPECT MPI before commencing radiotherapy and 12 months later were enrolled from January 2014 to December 2018. The images of CT simulation and SPECT MPI were integrated into the treatment planning system. The differences of doses and parameters of MPI in all cardiac subvolumes between left‐ and right‐sided breast cancer patients were analyzed. Results Patients with left‐sided breast cancer (n = 61) received a higher radiation dose to the heart, left ventricular, and its territories and subvolumes, compared to patients with right‐sided breast cancer (n = 19). The 20‐segment analysis also showed statistically significant disparities in the average radiation doses received by the two groups. In different coronary artery territories, the end‐diastolic perfusion and end‐systolic perfusion showed a decrease in both sides, with no significant differences. However, the wall motion and wall thickening showed a significant decline in subregions within the left‐ and right‐sided coronary artery territories. Conclusion This study demonstrates an innovative integrated method combining the left ventricular 20 regional doses with SPECT MPI which shows that left‐sided breast cancer patients receive a higher subvolume dose than right‐sided breast cancer patients. Further research is needed to confirm the potential impact on heart function after radiotherapy on both sides.

Published in Thoracic Cancer

ISSN: 1759-7706 (Print); 1759-7714 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://onlinelibrary.wiley.com/journal/17597714

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