Allergy, Asthma & Clinical Immunology (Dec 2022)
Diversity of malignancies in patients with different types of inborn errors of immunity
- Marzieh Tavakol,
- Samaneh Delavari,
- Fereshte Salami,
- Sarina Ansari,
- Seyed Erfan Rasouli,
- Zahra Chavoshzadeh,
- Roya Sherkat,
- Hamid Ahanchian,
- Soheila Aleyasin,
- Hossein Esmaeilzadeh,
- Nasrin Moazzen,
- Alireza Shafiei,
- Farhad Abolnezhadian,
- Sara Iranparast,
- Sareh sadat Ebrahimi,
- Tannaz Moeini Shad,
- Salar Pashangzadeh,
- Farzad Nazari,
- Arezou Rezaei,
- Ali Saeedi-Boroujeni,
- Mohammad Nabavi,
- Saba Arshi,
- Morteza Fallahpour,
- Mohammad hassan Bemanian,
- Samin Sharafian,
- Sima Shokri,
- Sarvin Eshaghi,
- Shiva Nazari,
- Bibi Shahin Shamsian,
- Mehrdad Dargahi Mal-Amir,
- Roya Khazaei,
- Pooya Ashkevari,
- Armin Khavandegar,
- Sabahat Haghi,
- Marzie Esmaeili,
- Hassan Abolhassani,
- Nima Rezaei
Affiliations
- Marzieh Tavakol
- Non-Communicable Diseases Research Center, Alborz University of Medical Sciences
- Samaneh Delavari
- Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences
- Fereshte Salami
- Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences
- Sarina Ansari
- Non-Communicable Diseases Research Center, Alborz University of Medical Sciences
- Seyed Erfan Rasouli
- Non-Communicable Diseases Research Center, Alborz University of Medical Sciences
- Zahra Chavoshzadeh
- Pediatric Infections Research Center, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences
- Roya Sherkat
- Acquired Immunodeficiency Research Center, Isfahan University of Medical Sciences
- Hamid Ahanchian
- Clinical Research Development Unit of Akbar Hospital, Mashhad University of Medical Sciences
- Soheila Aleyasin
- Allergy Research Center, Shiraz University of Medical Sciences
- Hossein Esmaeilzadeh
- Department of Pediatric Immunology and Allergy, Namazi Hospital, Shiraz University of Medical Sciences
- Nasrin Moazzen
- Allergy Research Center, Mashhad University of Medical Sciences
- Alireza Shafiei
- Department of Immunology, Bahrami Hospital, Tehran University of Medical Sciences
- Farhad Abolnezhadian
- Department of Pediatrics, Abuzar Children’s Hospital, Ahvaz Jundishapur University of Medical Sciences
- Sara Iranparast
- Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences
- Sareh sadat Ebrahimi
- Department of Immunology and Allergy, Kerman University of Medical Sciences
- Tannaz Moeini Shad
- Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences
- Salar Pashangzadeh
- Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences
- Farzad Nazari
- Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences
- Arezou Rezaei
- Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences
- Ali Saeedi-Boroujeni
- Department of Microbiology, School of Medicine, Abadan University of Medical Sciences
- Mohammad Nabavi
- Department of Allergy and Clinical Immunology, Rasool E Akram Hospital, Iran University of Medical Sciences
- Saba Arshi
- Department of Allergy and Clinical Immunology, Rasool E Akram Hospital, Iran University of Medical Sciences
- Morteza Fallahpour
- Department of Allergy and Clinical Immunology, Rasool E Akram Hospital, Iran University of Medical Sciences
- Mohammad hassan Bemanian
- Department of Allergy and Clinical Immunology, Rasool E Akram Hospital, Iran University of Medical Sciences
- Samin Sharafian
- Pediatric Infections Research Center, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences
- Sima Shokri
- Department of Allergy and Clinical Immunology, Rasool E Akram Hospital, Iran University of Medical Sciences
- Sarvin Eshaghi
- Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences
- Shiva Nazari
- Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences
- Bibi Shahin Shamsian
- Pediatric Hematologist-Oncologist, Congenital Hematological Disorders Research Center, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences
- Mehrdad Dargahi Mal-Amir
- Department of Pulmonology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences
- Roya Khazaei
- Department of Pulmonology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences
- Pooya Ashkevari
- Non-Communicable Diseases Research Center, Alborz University of Medical Sciences
- Armin Khavandegar
- Non-Communicable Diseases Research Center, Alborz University of Medical Sciences
- Sabahat Haghi
- Department of Hematology and Oncology, School of Medicine, Alborz University of Medical Sciences
- Marzie Esmaeili
- Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences
- Hassan Abolhassani
- Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences
- Nima Rezaei
- Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences
- DOI
- https://doi.org/10.1186/s13223-022-00747-2
- Journal volume & issue
-
Vol. 18,
no. 1
pp. 1 – 9
Abstract
Abstract Genetic defects in the development, maturation, and/or function of the immune cells can lead to Inborn errors of immunity (IEI) which may predispose patients to malignancies. The overall risk for cancer in children with IEI ranges from 4 to 25% and the type of malignancy is highly dependent on the specific mutant gene underlying IEI. We investigated 3056 IEI patients registered in the Iranian national registry between the years 1999 and 2020 in this retrospective cohort study. The frequency of malignancy and its association with the type of IEI in these patients were evaluated. A total of 82 IEI patients with malignancy were enrolled in this study. Among them, predominantly lymphoma was the most common type of malignancy (67.1%), followed by leukemia (11%), and cancers of the head and neck (7.3%). Among identified lymphoma cancers, non-Hodgkin’s lymphomas were the most frequent type (43.9%) followed by different subtypes of Hodgkin’s lymphoma (23.2%). Solid tumors (18.3%) appeared to be very heterogeneous by type and localization. The correlation between the type of malignancy and survival status and the association between the type of malignancy and IEI entities were unremarkable. The awareness of the association between the presence of IEI and cancer highlights the importance of a synergistic effort by oncologists and immunologists in the early diagnosis of malignancy and personalized therapeutic strategies in IEI patients.
Keywords
