Nature Communications (2021-02-01)

Structural basis for the biosynthesis of lovastatin

  • Jialiang Wang,
  • Jingdan Liang,
  • Lu Chen,
  • Wei Zhang,
  • Liangliang Kong,
  • Chao Peng,
  • Chen Su,
  • Yi Tang,
  • Zixin Deng,
  • Zhijun Wang

DOI
https://doi.org/10.1038/s41467-021-21174-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

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Biosynthesis of the statin precursor lovastatin depends on the LovB–LovC megasynthase complex. Here, the authors present cryoEM structures of LovB–LovC and core LovB, providing structural insights into the catalytic cycle underlying lovastatin production.