The effects of antioxidants, angioprotective agents, and vitamins on retina in complex retinal diseases

Abstract

I.V. Vorob’eva, A.A. Dement’eva, A. Dgebuadze Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation Treatment for complex retinal diseases in diabetic retinopathy and age-related macular degeneration (AMD) is still of crucial importance, in particular, in their early and preclinical stages to prevent vision loss. The approaches to treatment choice for AMD are well-known, i.e., various supplements containing antioxidants, vitamins, and microelements are prescribed at early stages. Available global published data highlight potentially beneficial effects of these supplements on the retina both in diabetic retinopathy and complex retinal diseases. Large-scale studies on supplements containing lutein, zeaxanthin, troxerutin, omega-3 polyunsaturated fatty acids, B vitamins, folic acid, vitamins E and C, and zinc were performed. It was demonstrated that these supplements can be used in complex retinal diseases. The mechanisms of action of these supplements at the cellular and molecular levels in two conditions are investigated worldwide. Ongoing animal researches will provide more  information. This review was performed in the light of social importance of these retinal diseases (i.e., diabetic retinopathy and AMD). Keywords: diabetic retinopathy, age-related macular degeneration, lutein, zeaxanthin, troxerutin, vitamins B, vitamin C, vitamin E, folic acid, zinc. For citation: Vorob’eva I.V., Dement’eva A.A., Dgebuadze A. The effects of antioxidants, angioprotective agents, and vitamins on retina in complex retinal diseases. Russian Journal of Clinical Ophthalmology. 2020;20(2):104–109. DOI: 10.32364/2311-7729-2020-20-2-104-109.