Nature Communications (Sep 2022)

Dominant role of DNA methylation over H3K9me3 for IAP silencing in endoderm

  • Zeyang Wang,
  • Rui Fan,
  • Angela Russo,
  • Filippo M. Cernilogar,
  • Alexander Nuber,
  • Silvia Schirge,
  • Irina Shcherbakova,
  • Iva Dzhilyanova,
  • Enes Ugur,
  • Tobias Anton,
  • Lisa Richter,
  • Heinrich Leonhardt,
  • Heiko Lickert,
  • Gunnar Schotta

DOI
https://doi.org/10.1038/s41467-022-32978-7
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 14

Abstract

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Silencing of endogenous retroviruses is crucial for maintaining transcriptional and genomic integrity of cells and is maintained by histone H3K9 methylation and/or DNA methylation in various cell types. Here the authors show that loss of DNA methyltransferase DNMT1 in endoderm results in ERV derepression while H3K9me3 is unaltered.