Effect of Glison index on survival of patients with localized prostate cancer in Samara region

Abstract

Prostate cancer is in third place in the structure of mortality in men. The most significant factor influencing the tactics of treatment and the likelihood of tumor progression after radical treatment is the degree of tumor malignancy. The aim of the study was to analyze the influence of the group of grade of malignancy of prostate adenocarcinoma on the survival rate of patients with localized forms in the Samara region. The study included all patients with newly diagnosed localized prostate cancer in the Samara region in 2010–2016 – 2535 patients registered in the database of the population cancer registry of the Samara Regional Clinical Oncological Dispensary. When analyzing the investigated indicator, the dependence of the general and cancer-specific survival of patients with localized prostate cancer on the degree of tumor malignancy is traced. In patients with an increase in tumor grade, the risk of death from prostate cancer increases.

Keywords

• prostate cancer
• survival
• intermediate-risk prostate cancer
• grade of prostate cancer