Nature Communications (Sep 2022)

A multi-adenylate cyclase regulator at the flagellar tip controls African trypanosome transmission

  • Sabine Bachmaier,
  • Giacomo Giacomelli,
  • Estefanía Calvo-Alvarez,
  • Larissa Rezende Vieira,
  • Jan Van Den Abbeele,
  • Aris Aristodemou,
  • Esben Lorentzen,
  • Matt K. Gould,
  • Ana Brennand,
  • Jean-William Dupuy,
  • Ignasi Forné,
  • Axel Imhof,
  • Marc Bramkamp,
  • Didier Salmon,
  • Brice Rotureau,
  • Michael Boshart

DOI
https://doi.org/10.1038/s41467-022-33108-z
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 17

Abstract

Read online

Trypanosomes can sense signal molecules and coordinate their movement in response to such signals, a phenomenon termed social motility (SoMo). Here, Bachmaier et al show that cyclic AMP response protein 3 (CARP3) localization to the flagellar tip and its interaction with a number of different adenylate cyclases is essential for migration to tsetse fly salivary glands and for SoMo, therewith linking SoMo and cAMP signaling to trypanosome transmission.