Nature Communications (Feb 2021)
Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors
- Jerzy Osipiuk,
- Saara-Anne Azizi,
- Steve Dvorkin,
- Michael Endres,
- Robert Jedrzejczak,
- Krysten A. Jones,
- Soowon Kang,
- Rahul S. Kathayat,
- Youngchang Kim,
- Vladislav G. Lisnyak,
- Samantha L. Maki,
- Vlad Nicolaescu,
- Cooper A. Taylor,
- Christine Tesar,
- Yu-An Zhang,
- Zhiyao Zhou,
- Glenn Randall,
- Karolina Michalska,
- Scott A. Snyder,
- Bryan C. Dickinson,
- Andrzej Joachimiak
Affiliations
- Jerzy Osipiuk
- Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago
- Saara-Anne Azizi
- Department of Chemistry, University of Chicago
- Steve Dvorkin
- Department of Microbiology, Ricketts Laboratory, University of Chicago
- Michael Endres
- Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago
- Robert Jedrzejczak
- Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago
- Krysten A. Jones
- Department of Chemistry, University of Chicago
- Soowon Kang
- Department of Microbiology, Ricketts Laboratory, University of Chicago
- Rahul S. Kathayat
- Department of Chemistry, University of Chicago
- Youngchang Kim
- Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago
- Vladislav G. Lisnyak
- Department of Chemistry, University of Chicago
- Samantha L. Maki
- Department of Chemistry, University of Chicago
- Vlad Nicolaescu
- Department of Microbiology, Ricketts Laboratory, University of Chicago
- Cooper A. Taylor
- Department of Chemistry, University of Chicago
- Christine Tesar
- Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago
- Yu-An Zhang
- Department of Chemistry, University of Chicago
- Zhiyao Zhou
- Department of Chemistry, University of Chicago
- Glenn Randall
- Department of Microbiology, Ricketts Laboratory, University of Chicago
- Karolina Michalska
- Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago
- Scott A. Snyder
- Department of Chemistry, University of Chicago
- Bryan C. Dickinson
- Department of Chemistry, University of Chicago
- Andrzej Joachimiak
- Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago
- DOI
- https://doi.org/10.1038/s41467-021-21060-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 9
Abstract
The SARS-CoV-2 papain-like protease (PLpro) is of interest as an antiviral drug target. Here, the authors synthesize and characterise naphthalene-based inhibitors for PLpro and present the crystal structures of PLpro in its apo state and with the bound inhibitors, which is of interest for further structure-based drug design efforts.
