Nature Communications (Dec 2018)

Structure of the type VI secretion system TssK–TssF–TssG baseplate subcomplex revealed by cryo-electron microscopy

  • Young-Jun Park,
  • Kaitlyn D. Lacourse,
  • Christian Cambillau,
  • Frank DiMaio,
  • Joseph D. Mougous,
  • David Veesler

DOI
https://doi.org/10.1038/s41467-018-07796-5
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

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Type VI secretion systems (T6SSs) translocate effector proteins into eukaryotic and bacterial recipient cells and are present in many Gram-negative bacteria. Here the authors present the 3.7 Å cryoEM structure of the E.coli T6SS baseplate wedge comprising TssK–TssF–TssG and propose a model for the T6SS baseplate and needle complex.