Journal of Medical Case Reports (Mar 2010)

Reduced uptake of the proliferation-seeking radiotracer technetium-99m-labelled pentavalent dimercaptosuccinic acid in a 47-year-old woman with severe breast epithelial hyperplasia taking ibuprofen: a case report

  • Marinopoulos Spyridon G,
  • Dimitrakakis Konstantinos E,
  • Stipsanelli Aikaterini J,
  • Ptohis Nikolaos D,
  • Sotiropoulou Maria G,
  • Tsaroucha Angeliki G,
  • Valsamaki Pipitsa N,
  • Sotiropoulou Evangelia K,
  • Papantoniou Vassilios J,
  • Tsiouris Spyridon T,
  • Antsaklis Aris J

DOI
https://doi.org/10.1186/1752-1947-4-89
Journal volume & issue
Vol. 4, no. 1
p. 89

Abstract

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Abstract Introduction Recent studies have reported a risk reduction in the progression of benign breast disease to breast carcinoma through COX-2 pathways. Case presentation We present a case of severe epithelial hyperplasia in a 47-year-old woman with increased breast density submitted to scintimammography by the proliferation-imaging tracer Technetium-99m-labelled pentavalent dimercaptosuccinic acid, before and after an oral ibuprofen treatment for 4 weeks. The radiotracer uptake after ibuprofen intake was significantly reduced, both visually and by semi-quantitative analysis, based on a calculation of lesion-to-background ratios. Conclusion In proliferating breast lesions, scintigraphically displayed reduction in Technetium-99m-labelled pentavalent dimercaptosuccinic acid uptake may indicate inhibition by ibuprofen in the pathway of malignant epithelial cell transformation.