INVESTIGATION OF CO-TRIMOXAZOLE EFFICIENCY USING THE EXPERIMENTAL TUBERCULOSIS MODEL IN MICE CAUSED BY TUBERCULOUS MYCOBACTERIA WITH EXTENSIVE DRUG RESISTANCE

Abstract

The efficiency of using co-trimoxazole for treatment of mice infected with tuberculous mycobacteria with extensive drug resistance and supposed sensitivity to co-trimoxazole have been investigated.The study of 78 clinical cultures of tuberculous mycobacteria has demonstrated that drug resistance to first line drugs (cases with multiple drug resistance – MDR) can be accompanied by the expansion of polymorphism in the part of drug susceptibility to co-trimoxazole, thus this drug can be used as an additional drug in the treatment of M/XDR tuberculosis patients. Using co-trimoxazole as an additional drug to isoniazid in the model of generalized tuberculosis in mice infected with Beijing strain with XDR reduced the bacterial load of the lungs by 10 times.Detail evaluation of drug susceptibility/resistance of tuberculous mycobacteria to the additional drug of co-trimoxazole and investigation of the interaction of this drug with other agents included into treatment regimens IV and V can form the basis for improvement of treatment regimens for M/XDR tuberculosis patients with specification of doses and frequency of drug in-takes for each specific case.

Keywords

• experimental tuberculosis in mice
• m/xdr tuberculosis
• drug susceptibility of m. tuberculosis to co-trimoxazole