Fe<sub>3</sub>O<sub>4</sub> Nanoparticles Functionalized with Polymer Ligand for T<sub>1</sub>-Weighted MRI In Vitro and In Vivo
Chenyang Xiang,
Xin Zhong,
Weitao Yang,
Muhammad Irfan Majeed,
Jun Wang,
Jiani Yu,
Jinming Hu,
Zushun Xu,
Bien Tan,
Bingbo Zhang,
Wei Yan
Affiliations
Chenyang Xiang
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education, Key Laboratory of Green Preparation and Application for Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science & Engineering, Hubei University, Wuhan 430062, China
Xin Zhong
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education, Key Laboratory of Green Preparation and Application for Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science & Engineering, Hubei University, Wuhan 430062, China
Weitao Yang
The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200443, China
Muhammad Irfan Majeed
School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
Jun Wang
The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200443, China
Jiani Yu
The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200443, China
Jinming Hu
CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Anhui 230026, China
Zushun Xu
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education, Key Laboratory of Green Preparation and Application for Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science & Engineering, Hubei University, Wuhan 430062, China
Bien Tan
School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
Bingbo Zhang
The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200443, China
Wei Yan
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education, Key Laboratory of Green Preparation and Application for Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science & Engineering, Hubei University, Wuhan 430062, China
Magnetic resonance imaging (MRI) has gained wide interest in early accurate diagnoses due to the high resolution and low toxicity of magnetic nanoparticles. In order to develop potential alternatives of toxic Gd- or Mn-based chelating agents, we report the synthesis of water soluble ultra-small Fe3O4 nanoparticles by a modified co-precipitation method as T1-weighted positive contrast agents. The magnetic iron oxide nanoparticles (MIONs) were functionalized by polymer ligand dodecanthiol-polymethacrylic acid (DDT-PMAA) to enhance their colloidal stability. These MIONs have high longitudinal relaxivity (r1 = 8.18 mM−1·S−1) and exhibited good results in the in vitro and in vivo MR imaging. No toxicity was observed in cytotoxicity assay and histology toxicity analysis. The MIONs@DDT-PMAA(magnetic iron oxide nanoparticles @ dodecanthiol-polymethacrylic acid) present great potential as positive contrast agents for tumor diagnosis.
