Nature Communications (Jul 2017)
The m6A pathway facilitates sex determination in Drosophila
- Lijuan Kan,
- Anya V. Grozhik,
- Jeffrey Vedanayagam,
- Deepak P. Patil,
- Nan Pang,
- Kok-Seong Lim,
- Yi-Chun Huang,
- Brian Joseph,
- Ching-Jung Lin,
- Vladimir Despic,
- Jian Guo,
- Dong Yan,
- Shu Kondo,
- Wu-Min Deng,
- Peter C. Dedon,
- Samie R. Jaffrey,
- Eric C. Lai
Affiliations
- Lijuan Kan
- Department of Developmental Biology, Sloan-Kettering Institute
- Anya V. Grozhik
- Department of Pharmacology, Weill Medical College, Cornell University
- Jeffrey Vedanayagam
- Department of Developmental Biology, Sloan-Kettering Institute
- Deepak P. Patil
- Department of Pharmacology, Weill Medical College, Cornell University
- Nan Pang
- Department of Developmental Biology, Sloan-Kettering Institute
- Kok-Seong Lim
- Department of Biological Engineering, Massachusetts Institute of Technology
- Yi-Chun Huang
- Department of Biological Science, Florida State University
- Brian Joseph
- Department of Developmental Biology, Sloan-Kettering Institute
- Ching-Jung Lin
- Department of Developmental Biology, Sloan-Kettering Institute
- Vladimir Despic
- Department of Developmental Biology, Sloan-Kettering Institute
- Jian Guo
- Key Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Dong Yan
- Key Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Shu Kondo
- Invertebrate Genetics Laboratory, National Institute of Genetics
- Wu-Min Deng
- Department of Biological Science, Florida State University
- Peter C. Dedon
- Department of Biological Engineering, Massachusetts Institute of Technology
- Samie R. Jaffrey
- Department of Pharmacology, Weill Medical College, Cornell University
- Eric C. Lai
- Department of Developmental Biology, Sloan-Kettering Institute
- DOI
- https://doi.org/10.1038/ncomms15737
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
N6-methyladenosine (m6A) is a conserved RNA modification that has recently emerged as an important regulator of messenger RNA processing and activity. Here, the authors provide evidence that m6A pathway facilitates female-specific splicing of Sxl, regulating sex determination in Drosophila.
