PLoS ONE (Jan 2022)

Incidence of cervical, breast and colorectal cancers between 2010 and 2015 in people living with HIV in France.

  • Teresa Rojas Rojas,
  • Isabelle Poizot-Martin,
  • David Rey,
  • Claudine Duvivier,
  • Firouzé Bani-Sadr,
  • André Cabie,
  • Pierre Delobel,
  • Christine Jacomet,
  • Clotilde Allavena,
  • Tristan Ferry,
  • Pascal Pugliese,
  • Marc-Antoine Valantin,
  • Isabelle Lamaury,
  • Laurent Hustache-Matthieu,
  • Anne Fresard,
  • Tamazighth Houyou,
  • Thomas Huleux,
  • Antoine Cheret,
  • Alain Makinson,
  • Véronique Obry-Roguet,
  • Caroline Lions,
  • Maria Patrizia Carrieri,
  • Camelia Protopopescu,
  • Dat’AIDS Study Group

DOI
https://doi.org/10.1371/journal.pone.0261069
Journal volume & issue
Vol. 17, no. 3
p. e0261069

Abstract

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BackgroundWe aimed to evaluate the incidence rates between 2010 and 2015 for invasive cervical cancer (ICC), breast cancer (BC), and colorectal cancer (CRC) in people living with HIV (PLWH) in France, and to compare them with those in the French general population. These cancers are targeted by the national cancer-screening program.SettingThis is a retrospective study based on the longitudinal data of the French Dat'AIDS cohort.MethodsStandardized incidence ratios (SIR) for ICC and BC, and incidence rates for all three cancers were calculated overall and for specific sub-populations according to nadir CD4 cell count, HIV transmission category, HIV diagnosis period, and HCV coinfection.ResultsThe 2010-2015 CRC incidence rate was 25.0 [95% confidence interval (CI): 18.6-33.4] per 100,000 person-years, in 44,642 PLWH (both men and women). Compared with the general population, the ICC incidence rate was significantly higher in HIV-infected women both overall (SIR = 1.93, 95% CI: 1.18-3.14) and in the following sub-populations: nadir CD4 ≤ 200 cells/mm3 (SIR = 2.62, 95% CI: 1.45-4.74), HIV transmission through intravenous drug use (SIR = 5.14, 95% CI: 1.93-13.70), HCV coinfection (SIR = 3.52, 95% CI: 1.47-8.47) and HIV diagnosis before 2000 (SIR = 2.06, 95% CI: 1.07-3.97). Conversely, the BC incidence rate was significantly lower in the study sample than in the general population (SIR = 0.56, 95% CI: 0.42-0.73).ConclusionThe present study showed no significant linear trend between 2010 and 2015 in the incidence rates of the three cancers explored in the PLWH study sample. Specific recommendations for ICC screening are still required for HIV-infected women and should focus on sub-populations at greatest risk.