Intracellular energy controls dynamics of stress-induced ribonucleoprotein granules

Tao Wang; Xibin Tian; Han Byeol Kim; Yura Jang; Zhiyuan Huang; Chan Hyun Na; Jiou Wang

doi:10.1038/s41467-022-33079-1

Nature Communications (Sep 2022)

Intracellular energy controls dynamics of stress-induced ribonucleoprotein granules

Tao Wang,
Xibin Tian,
Han Byeol Kim,
Yura Jang,
Zhiyuan Huang,
Chan Hyun Na,
Jiou Wang

Affiliations

Tao Wang: Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University
Xibin Tian: Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University
Han Byeol Kim: Department of Neurology, Institute for Cell Engineering, School of Medicine, Johns Hopkins University
Yura Jang: Department of Neurology, Institute for Cell Engineering, School of Medicine, Johns Hopkins University
Zhiyuan Huang: Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University
Chan Hyun Na: Department of Neurology, Institute for Cell Engineering, School of Medicine, Johns Hopkins University
Jiou Wang: Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University

DOI: https://doi.org/10.1038/s41467-022-33079-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 21

Abstract

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Stress granules are associated with neurodegenerative diseases. Here, Wang et al. found intracellular energy deficiencies trigger a unique type of granules and disrupt granule disassembly through 4EBP1/eIF4A.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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