Rapid differentiation of hiPSCs into functional oligodendrocytes using an OLIG2 synthetic modified messenger RNA

Jian Xu; Zhihua Yang; Rui Wang; Fumei He; Rong Yan; Yidi Zhang; Liying Yu; Wenbin Deng; Yichu Nie

doi:10.1038/s42003-022-04043-y

Communications Biology (Oct 2022)

Rapid differentiation of hiPSCs into functional oligodendrocytes using an OLIG2 synthetic modified messenger RNA

Jian Xu,
Zhihua Yang,
Rui Wang,
Fumei He,
Rong Yan,
Yidi Zhang,
Liying Yu,
Wenbin Deng,
Yichu Nie

Affiliations

Jian Xu: School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University
Zhihua Yang: Stroke Center, The Fifth Affiliated Hospital of Guangzhou Medical University
Rui Wang: Clinical Research Institute, The First People’s Hospital of Foshan
Fumei He: School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University
Rong Yan: Clinical Research Institute, The First People’s Hospital of Foshan
Yidi Zhang: School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University
Liying Yu: Stroke Center, The Fifth Affiliated Hospital of Guangzhou Medical University
Wenbin Deng: School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University
Yichu Nie: School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University

DOI: https://doi.org/10.1038/s42003-022-04043-y
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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The use of synthetic modified messenger RNA (smRNA) allows for the differentiation of human-induced pluripotent stem cells (hiPSCs) into lineage-specific oligodendrocytes.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal