Activating alternative transport modes in a multidrug resistance efflux pump to confer chemical susceptibility

Peyton J. Spreacker; Nathan E. Thomas; Will F. Beeninga; Merissa Brousseau; Colin J. Porter; Kylie M. Hibbs; Katherine A. Henzler-Wildman

doi:10.1038/s41467-022-35410-2

Nature Communications (Dec 2022)

Activating alternative transport modes in a multidrug resistance efflux pump to confer chemical susceptibility

Peyton J. Spreacker,
Nathan E. Thomas,
Will F. Beeninga,
Merissa Brousseau,
Colin J. Porter,
Kylie M. Hibbs,
Katherine A. Henzler-Wildman

Affiliations

Peyton J. Spreacker: Department of Biochemistry, University of Wisconsin-Madison
Nathan E. Thomas: Department of Biochemistry, University of Wisconsin-Madison
Will F. Beeninga: Department of Biochemistry, University of Wisconsin-Madison
Merissa Brousseau: Department of Biochemistry, University of Wisconsin-Madison
Colin J. Porter: Department of Biochemistry, University of Wisconsin-Madison
Kylie M. Hibbs: Department of Biochemistry, University of Wisconsin-Madison
Katherine A. Henzler-Wildman: Department of Biochemistry, University of Wisconsin-Madison

DOI: https://doi.org/10.1038/s41467-022-35410-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Antibiotic resistance through multidrug efflux is a major hurdle in antibiotic development. Here, authors experimentally demonstrate that EmrE, a small multidrug resistance efflux pump from E. coli, can confer resistance or susceptibility depending on the small molecule substrate.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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