AMELIORATIVE EFFECTS OF VITAMIN E AND SELENIUM ON BLEOMYCIN-INDUCED MALE INFERTILITY

Abstract

Bleomycin (BL) is a well-known anticarcinogenic chemotherapy that is used for the remedy of numerous varieties of most cancers. However, the use of BL became connected to the prevalence of several unfavorable results together with skin and lung fibrosis and testicular cancer. Dietary micronutrients such as vitamin E, and selenium (Se) are gambling critical roles in maintaining the health of human and animals and preserving the cell redox status homeostasis through their antioxidant roles. The objectives of the current investigation had been to investigate BL-induced male infertility in Albino rats. The protecting effects of either vitamin E, or Se towards such detrimental outcomes had been additionally examined. Moreover, the potential mechanisms behind such adverse effects had been evaluated. The obtained results indicated significant reduction in the testosterone, FSH, and LH levels in the BL-treated group. Likely, sperm characteristics as sperm count and motility had been significantly reduced in BL-treated group. Such changes have been associated with a significant reduction within the antioxidant enzymes including CAT, GPx, SOD, and MDA. Interestingly, co-exposure of experimental rats to either BL with vitamin E, or Se had notably parameters relatively close to the normal levels suggesting the ameliorative effects of vitamin E and Se towards BL-induced male infertility.

Keywords

• Bleomycin
• selenium
• vitamin E
• vale fertility